R. Hezekiah's reputation rests upon his Peri Hadash, which contains exceptionally trenchant criticisms of the rulings of R. Joseph Caro and all the earlier codifiers, with the exception of Maimonides. In this work, aimed at nullifying the authority of the Shulhan Arukh as representing the final halakhah, he attempts to elucidate the halakhah as conforming with his view. He also added his own novellae. He inclines to leniency in his rulings, taking to task those authorities who adopt a stringent line. The section Yoreh De'ah was published in Amsterdam in 1692, while R. Hezekiah was on a mission there from Jerusalem; the section on parts of Orah Hayyim and Hilkhot Gittin in 1706, and that on the whole of Orah Hayyim in 1730. When the volume on Yoreh De'ah reached Egypt it gave rise to violent controversy. The Egyptian rabbis even thought of excommunicating him but instead they ordered the book to be suppressed and issued a ban against anyone studying it, which was later repealed, however, by R. Abraham ha-Levi, the rabbi of Egypt. In the course of time, the work increased in popularity, many leading halakhists accepting its rulings. R. Jonathan Eybeschuetz in his Kereti u-Feleti (Altona, 1763), and R. Joseph Teomim in Peri Megadim quote him regularly and rule in conformity with his view. The work was published later in the editions of the Shulhan Arukh together with the other standard commentaries—in Yoreh De'ah (Amsterdam, 1743), in Orah Hayyim (1754), in Hilkhot Gittin (Vienna, 1809). The publishers softened, in some degree, the sharpness of its language, and omitted the harsh expressions used against the Shulhan Arukh and other halakhists, making it conform in style to other commentaries. Among those who strove to rebut its trenchant criticism were R. Hananiah Cases in Hok le-Yisrael (Leghorn, 1740), R. Hayyim ibn Attar, who in his Perot Ginnosar (Amsterdam, 1742) gives the Peri Hadash on Yoreh De'ah together with his criticisms entitled Peri To'ar, and R. Zevi Ashkenazi (the "Hakham Zevi"), whose conclusions were published in the periodical Sha'arei Torah (cf. bibliography). R. Hezekiah also wrote: Mayim Hayyim (Amsterdam, 1730), novellae on Maimonides, and responsa.